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KMID : 0812020130190010061
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Korean Journal of Neurogastroenterology and Motility
2013 Volume.19 No. 1 p.61 ~ p.69
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Comparison of Gastroesophageal Reflux Disease Symptoms and Proton Pump Inhibitor Response Using Gastroesophageal Reflux Disease Impact Scale Questionnaire
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Jo So-Young
Kim Na-Young
Lim Ji-Hwan
Shin Cheol-Min
Park Young-Soo
Lee Dong-Ho
Jung Hyun-Chae
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Abstract
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Background/Aims To compare gastroesophageal reflux disease (GERD) symptoms and response to proton pump inhibitor (PPI) in patients with erosive esophagitis (EE), non-erosive reflux disease (NERD) or functional heartburn (FH) using GERD impact scale (GIS) questionnaire. Methods Total 126 patients with GERD symptoms were diagnosed as EE (n = 62), NERD (n = 34) and FH (n = 30) by endoscopy, 24-hour esophageal pH testing and Bernstein test, prospectively. Analysis of risk factors and GIS questionnaire for GERD symptoms and quality of life were performed before and 8 weeks after PPI treatment. Results EE group had a higher proportion of men, frequent alcohol consumption, smoking, hiatal hernia, body mass index ≥ 25 kg/m2 and triglyceride levels (≥ 150 mg/dL) than the other groups (all P ＜ 0.05). On the other hand, both psychiatric treatment and psychopharmacotherapy were more frequent in patients with FH than in those with EE and NERD (both P ＜ 0.05). Among GERD symptoms, chest pain was more frequent in FH group than in EE and NERD groups (P ＜ 0.05). Eating problems and limitation of productive daily activities occurred frequently in FH group and NERD group, respectively. GIS after 8 week PPI treatment showed improvement in all of the GERD symptoms in EE (all P ＜ 0.05) and in acid regurgitation, epigastric pain and hoarseness in NERD group (all P ＜ 0.05). In terms of quality of life, PPI treatment improved sleep disturbance in EE (P = 0.031) and limitation of productive activity in the NERD group (P = 0.001). Conclusions GIS questionnaire showed that different characteristics and symptoms improved after PPI therapy among patients with EE, NERD and FH, demonstrating the usefulness of the GIS questionnaire.
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KEYWORD
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Functional heartburn, Gastroesophageal reflux, Proton pump inhibitors, Quality of life, Questionnaires
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